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SF 11

Name: SF 11
Brand: TargetMol
SKU: T23349
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23349Cas No. 443292-81-7

SF 11 is a potent, brain-penetrant neuropeptide Y Y2 receptor antagonist with an IC50 of 199 nM, exhibiting antidepressant-like activity.

SF 11

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Purity: 99.51%

Catalog No. T23349Cas No. 443292-81-7

SF 11 is a potent, brain-penetrant neuropeptide Y Y2 receptor antagonist with an IC50 of 199 nM, exhibiting antidepressant-like activity.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$31	-	In Stock
5 mg	$51	-	In Stock
10 mg	$83	-	In Stock
25 mg	$167	-	In Stock
50 mg	$293	-	In Stock
100 mg	$453	-	In Stock
200 mg	$609	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.51%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

SF 11 AI Summary

SF 11 exhibits a diverse range of bioactivities. It functions as an inhibitor of several targets, including Lamin A splicing, 12-human lipoxygenase, Influenza NS1 Protein, Menin-MLL interaction, JMJD2A-Tudor Domain, Rango-Importin beta complex formation, HP1-beta Chromodomain interactions, TGF-b, Marburg Virus cell entry, Pin1, human tyrosyl-DNA phosphodiesterase 1, as well as GLP-1 receptor inverse agonism and agonism. Notably, it shows potent antagonistic activity at the neuropeptide Y receptor Y2, with IC50 values reported as 190.0 nM and 200.0 nM. Additionally, it displays antiviral properties against SARS-CoV-2 by inhibiting virus-induced cytotoxicity in Caco-2 and VERO-6 cells. The compound shows some inhibition of the SARS-CoV-2 3CL-Pro protease, with inhibition percentages of 8.45% and 20.18% at 20µM. Moreover, SF 11 demonstrates inhibitory activity on the human HDAC6 enzyme, with varied inhibition percentages depending on the peptide substrate used..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	SF 11 is a potent, brain-penetrant neuropeptide Y Y2 receptor antagonist with an IC50 of 199 nM, exhibiting antidepressant-like activity.
Targets&IC50	NPYY2 receptor:199 nM (IC50)

Chemical Properties

Molecular Weight	446.6
Formula	C₂₇H₃₀N₂O₂S
Cas No.	443292-81-7
Smiles	C(O)(C1CCN(C(NC2=CC=C(OCC)C=C2)=S)CC1)(C3=CC=CC=C3)C4=CC=CC=C4
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 22.33 mg/mL, Sonication is recommended.

DMSO: 40 mg/mL (89.57 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2391 mL	11.1957 mL	22.3914 mL	111.9570 mL
5 mM	0.4478 mL	2.2391 mL	4.4783 mL	22.3914 mL
10 mM	0.2239 mL	1.1196 mL	2.2391 mL	11.1957 mL
20 mM	0.1120 mL	0.5598 mL	1.1196 mL	5.5979 mL
50 mM	0.0448 mL	0.2239 mL	0.4478 mL	2.2391 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc